4.8/5 based on 14,234+ customers

Total Renew - Advanced Joint, Muscle and Nerve Relief Protocol

Title

Professionally reviewed and tested

Clinically tested active ingredients, lab-analyzed for purity, potency, and heavy metals.

Title

Deep-penetrating formula

Triple-action technology

Clinically-tested actives

Non-greasy, odor-free

Ships by Sat, Aug 08

60-Day Money Back Guarantee

Try it for two full months. If you're not satisfied, contact us for 100% of your money back. No questions asked.

WARNING: Low Stock Notice

This product sold out 12 times last year. We encourage you to take advantage of the limited sale and buy now. Subscribing protects you against future stock outs.

PS: Only available here, don’t buy fakes on Amazon/eBay

As Seen On:

Healthline PubMed Women's Health Forbes BBC
Don't Take Our Word For It

Join 22,500+ People Who Finally Found Relief

★★★★★ Rated 4.9 / 5.0 · 1,612+ reviews
Robert M., verified Total Renew buyer

"I walked her down that aisle"

★★★★★ 5.0

For three years, I used a walker just to get from the bedroom to the kitchen.

Six weeks into Total Renew, I realized the walker was still against the wall — and I'd completely forgotten about it.

On my daughter's wedding day, I took her arm and walked her down that aisle without thinking about my knees once.

— Robert M., 67Verified Buyer
Gloria T., verified Total Renew buyer

"It wasn't about the shoes"

★★★★★ 5.0

For seven years, my husband Hank knelt in front of me every morning to put on my shoes. He never complained. But every time, something inside me broke a little.

In week five of Total Renew, I bent down and did it myself — no pain, no help.

It wasn't about the shoes. It was about my dignity.

— Gloria T., 62Verified Buyer
Arthur B., verified Total Renew buyer

"My hands are back"

★★★★★ 5.0

When arthritis took my fingers, I couldn't hold a screwdriver or button my own shirt.

After seven weeks of applying Total Renew, I sat at my workbench and repaired two watches in the same week.

My hands are back. And honestly, so am I.

— Arthur B., 73Verified Buyer
Linda W., verified Total Renew buyer

"I canceled the surgery"

★★★★★ 5.0

I used to make excuses every time Sophie asked me to play outside. I had a knee replacement scheduled and I was terrified.

Six weeks into Total Renew, I canceled the surgery.

Eight weeks in, I pushed her on those swings until my arms got tired — not my knees.

— Linda W., 68Verified Buyer
Editorial illustration of the joint area and cartilage
Clinically-Studied Ingredients

Designed to Address What Most Creams Miss

You've bought the tubes. The cold one. The hot one. The one the pharmacist recommended.

They all do the same thing: numb the feeling for an hour or two. Numbing isn't the same as helping. The hour passes and you're reaching for the tube again before dinner.

  • Stairs you take one at a time, holding the rail, hoping nobody's watching
  • Fingers that won't close around a coffee mug in the morning
  • Getting out of the car turned into a whole production
  • Things you gave up — the garden, the morning loop — without ever deciding to
Here's what those creams never reach. Researchers point to a group of enzymes your own body produces — called MMPs — as part of how cartilage wears thin over time. Thinner cushioning, less comfort. Total Renew was formulated to act there, not on the sensation.
Total Renew jar

Standard Creams Stop at the Surface. This One Was Built to Go Through It.

Where Most Creams Stop

At the surface. A cooling or warming sensation, twenty minutes of distraction, and nothing reaching the place the discomfort is coming from. You feel something. That's not the same as supporting something.

Where Total Renew Is Designed to Go

Total Renew uses a deep-penetrating delivery system formulated to carry clinically-studied compounds through the skin and into the joint area — no detour through the stomach, no absorption loss. Straight to where the support is wanted.

Through the skin. Into the joint area.
That's Triple-Action Technology.
Nature's Best in Balance

Pure and Natural Ingredients

Honeycomb, the source of Melittin

Melittin

The Cornerstone of the Formula

Studies have looked at how Melittin, applied to the skin, gets through it to reach joint tissue — and at how it interacts with the enzymes tied to cartilage wear. It's expensive and hard to source, so most brands skip it. We built the whole formula around it.

Boswellia serrata resin

Boswellia Serrata

The Calming Resin

A tree resin studied for its effect on the same pathways researchers link to joint discomfort. It works alongside Melittin to support a calmer, more comfortable joint.

Low-molecular-weight hyaluronic acid

Hyaluronic Acid

The Glide Factor

Standard hyaluronic acid sits on the skin and never gets in. The version we use is small enough to pass through — formulated to support the fluid that keeps the joint gliding. Less grinding. More glide.

Chamomile flowers, the source of apigenin

Apigenin

From Chamomile Flowers

Studies have examined how it interacts with two of the enzymes involved in cartilage wear — and how topical chamomile relates to comfort and movement in stiff knees.

Type II collagen

Type II Collagen

Built for the Long Run

Built small enough to be absorbed through the skin instead of stopping at the surface. Studies have explored how the body responds to this form of collagen — one reason it's part of the long protocol.

Five actives, one job: get past the skin and support the joint underneath. Non-greasy. Odor-free. Nothing you can't pronounce.

One Jar, Six Places

Where You Can Use It

A little goes a long way. Put it wherever the day gives you trouble.

Applying Total Renew to the knees

Knees

Stairs, getting out of the car, the walk you stopped taking.

Applying Total Renew to the shoulders

Shoulders

Reaching the top shelf yourself instead of asking.

Applying Total Renew to the hips

Hips

Kneeling in the garden. Getting up out of a low chair.

Applying Total Renew to the fingers

Fingers

Buttoning a shirt. Holding a screwdriver steady.

Applying Total Renew to the lower back

Lower Back

Bending to load the washer. Sitting through a long drive.

Applying Total Renew to the hands and feet

Hands & Feet

Gripping a mug in the morning. Standing through dinner prep.

What Many People Notice, Week by Week

Every body is different. This is the pattern our customers describe most often.

Weeks 1–2
It Starts

Apply it once a day to whatever bothers you. It sinks in clean — no grease, no smell. Most people notice the first small thing here: a morning that starts a little easier.

  • Mornings reported as easier to get going
  • Knees, hands, shoulders, hips or lower back

The ordinary things start coming back. Stairs with the laundry basket. Fingers closing around a coffee mug. Things you'd stopped expecting to get back.

  • Everyday movements reported as easier
  • Comfort that lasts past the application
Weeks 3–8
You Notice It
Weeks 9–16
It Builds

Around month three the stories change shape. Plates back on the top shelf. A full round of golf. The garden row planted by hand instead of watched from a chair.

  • Activities you'd shelved start coming back
  • A good point to check in with your doctor

This is the stretch most people skip, and it's the one that matters most. Joints answer to time, not to a strong start. The longer you stay with it, the more you keep — and what you build here tends to hold after you finish.

  • The longer the run, the more people hold onto
  • Why the multi-jar protocols exist
Weeks 17–24
Keep Going
Why Total Renew?

What a Real Protocol Looks Like Next to a Tube

  Total Renew Standard Joint Cream
Deep-penetrating delivery system
Formulated to act on cartilage wear, not just the feeling
Studied actives with a defined roleFiveOne or none
Lab-analyzed for purity, potency, heavy metalsVaries
Non-greasy, odor-freeVaries
Use on multiple joints at onceVaries
60-day money-back guaranteeVaries
Professionally Reviewed and Tested

Backed by 100+ Studies on Joint Comfort and Mobility

Every active here was chosen because researchers had already asked a question about it — how Melittin gets through skin, how the cartilage-wearing enzymes behave, how small hyaluronic acid has to be to pass through at all.

And what's on the label is what's in the jar: active ingredients lab-analyzed for purity, potency and heavy metals, batch by batch.

Third-party tested. Every batch.
Total Renew quality and batch testing
60-day money back guarantee badge

60-Day Money-Back Guarantee

Here's the deal: Give Total Renew two full months. Apply it daily. Pay attention to how you feel.

If at the end of 60 days you're not genuinely happy with the difference — for any reason at all, or no reason — just send our team an email and we'll refund every dollar. No questions. No hoops. No "send the jars back" runaround.

You keep the jars. We send you the money. That's it.

We can offer that because we know what happens when people actually use Total Renew the way it was designed to be used. The risk is entirely ours. All you have to do is start.

Reviews

Why 22,500+ People Swear By Total Renew

22,500+ customers, and the stories keep sounding the same. Here's a sample, unedited.

4.9
out of 5.0
★★★★★
Based on 1,612 reviews
Rated Excellent
5 star 92%
4 star 6%
3 star 1%
2 star 1%
1 star 0%
★★★★★Verified

Tried every cream at the pharmacy, none lasted more than an hour. This one's different. Took a few weeks but now I do the basement stairs with the laundry and don't even think about it.

Carol D., 66
★★★★★Verified

My fingers wouldn't close around my coffee mug in the mornings. Been using it on my hands about a month now and I'm gripping the mug again. Doesn't smell either, which is a plus.

Wayne T., 71
★★★★★Verified

Buddy and I do our whole morning loop again. Used to cut it in half cuz of my knees. Not anymore.

Pat S., 63
★★★★★Verified

Shoulder had me asking my wife to reach the top shelf for years. Put it on every day, gave it time, and by month two I'm putting the plates away myself. Felt like getting something back.

Harold M., 74
★★★★★Verified

Getting out of the car used to be a whole production. Now I just swing my legs out and go. Not greasy, no weird smell. Happy customer.

Janet R., 68
★★★★★Verified

Gave up my garden two summers ago, my lower back couldn't take the kneeling. This spring I planted the whole row myself. Wish I'd found this stuff sooner honestly.

Bill K., 70
★★★★★Verified

Told my husband I'd just watch at our anniversary. Ended up dancing the whole song. He didn't say anything, just held on. That says it all.

Donna F., 65
★★★★☆Verified

Didn't feel much the first couple weeks and almost quit. Glad I stuck with it. Played a full 18 by week seven and woke up fine. Only knock is I wish it kicked in faster.

Eugene W., 72
★★★★★Verified

My hands had quit on me. Finished a whole baby blanket for my granddaughter last week, first thing I've made in years. Works if you're consistent with it.

Sharon L., 69
Load More Reviews
Frequently Asked Questions

Everything You Want to Know Before You Order

How is Total Renew different from other joint creams I've tried before?
Most creams work on the feeling — a cooling or warming sensation that fades in minutes. Total Renew was formulated to act deeper: a delivery system built to carry its actives through the skin to the joint area, where the enzymes tied to cartilage wear are at work. It's a protocol, not a quick trick.
I'm 75 years old. Is my condition too advanced for this to work?
Not even close. Total Renew is designed for adults of every age looking to support their joint comfort and daily mobility — and some of our happiest customers are in their 70s and 80s. The formula is gentle enough for daily use and works best when applied consistently across the full 24-week protocol. Age is not the obstacle people think it is.
Can I take Total Renew with other supplements or medications?
Total Renew is a topical cream made with natural ingredients, so it's generally easy to incorporate alongside other wellness products. That said, if you're managing a medical condition or taking prescription medication, we always recommend a quick chat with your healthcare provider before adding anything new to your routine.
How soon will I start to feel results?
Most customers tell us they notice the first small changes within the first few weeks. Some sooner. The 24-week protocol exists because joints answer to time — the longer you stay with it, the more you tend to keep.
How much should I order?
Honestly? As much as you can. The protocol runs 24 weeks for a real reason — joints answer to time, and the customers who go all-in on the 6-jar package are the ones who write us the stories you read above. The per-jar price drops, shipping is free, and you're covered by the 60-day guarantee. If you'd rather try it first, the 2-jar option is a fine place to start — but re-orders aren't guaranteed at today's discount.
Can I use Total Renew on multiple joints at the same time?
Absolutely. Many customers apply Total Renew to knees, hands, shoulders, hips and lower back — wherever they want a little extra comfort. A small amount goes a long way, so a single jar covers more ground than you'd expect.
Is there anyone who should NOT use Total Renew?
Total Renew is made with natural ingredients and is well-tolerated by most adults. However, if you're allergic to bee products, pregnant, nursing, or managing a medical condition, please consult a qualified healthcare professional before use.
How long does shipping take?
Delivery times vary depending on your location. For the United States, delivery generally takes 10 to 15 business days. For other countries, it can range from 10 to 20 business days, depending on the region. Once your order is dispatched from NatureOne Lab facilities, you'll receive a tracking code via email and SMS to track the delivery in real time to your door.
What if it doesn't work for me?
Then you don't pay for it. Contact our team within 60 days and we'll refund every dollar — and you keep the jars. No forms, no return shipping, no explanation required. The risk is entirely ours. Always has been.